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TCF7L2 and weight loss

There are some genes that widely known to be related to weight regulation. Some of them play important role in adipogenesis, while the others regulate glucose metabolism. TCF7L2 or transcription factor 7 like 2 is a gene that encode protein involved in blood glucose homeostasis. Interestingly, this gene is reported not only regulates glucose metabolism … Baca lebih lanjut

If you paid it, you really want to lose it: a study shown how a commercial weight loss program works.

A study in Sweden shown that weight loss commercial program works. The basic idea is simple, you want to get something that you have already paid for. This cohort study done to examine how a commercial weight loss program suceed to lose weight and how much dropouts that they got. In the study, they used … Baca lebih lanjut

Exercise and beyond: improvement of SOD and the role of oxidative stress

Exercise is good for your health that, my grandmother knows that. A routine exercise is able to help you reduce weight and prevent weight gain, public secret. But how can exercise help against obesity, the answer is not as simple as just doing the math. Farias et al from the laboratory of biochemistry and physiology, … Baca lebih lanjut

Oxygen, hypoxia, oxygen tension in human obesity

A new review published from current opinion clinical nutrition and metabolism. And this is worth attention. There is a growing number of studies investigating on the role of oxygen in development of obesity. In obese mice, its been reported that there are changes in morphology of mithocondria, reduction on mitochondrial biogenesis and mass and more … Baca lebih lanjut

Hypoxia in fat cells, what microarray said..

Finally released… After several speculations and controversies about how hypoxia on adipose tissue would affect the behaviour of this tissue, some research group finally revealed some interesting findings. In this blog i am going to comment about two published article on this very interesting field. Firstly, last year PlosOne published an article written by groups … Baca lebih lanjut

Anti-hypoxia works as anti-obesity… New obesity treatment is found???

It is just recently published in PlosOne journal that Shin et al. successfully reduce body weight of diet induced obesity using HIF-1 alpha antisense oligonucleotide or ASO. HIF-1 alpha or hypoxia inducible factor-1 is protein that expressed when oxygen in the cell or tissue are low. This protein is sensitive to oxigen level in human … Baca lebih lanjut

Trained individuals prefer using fat from muscle than from adipocyte

The ability of our body shift from using carbohydrate into fat defines our adaptation to exercise, especially endurance training. One of the most debatable properties of trained individuals is their ability to produce less cathecolamine even in the same workload with untrained individuals. There is a study shown that plasma cathecolamine of trained individual dropped … Baca lebih lanjut

Lactic acid… The byproduct of anaerobic metabolism works as anti- lipolytic during exercise.

Using fat as source of energy during exercise is crucial. This make sure that muscle is able to work even though glucose is already depleted. And one of the most important process to provide fat during this exercise is lipolysis. This process happeneds both in muscle cells and adipocytes. Four hormones regulate lipolysis during exercise, … Baca lebih lanjut

The role of adrenergic receptor on obesity, how the story started and where we are now?

Its just this morning, I sit down and read some old publications made group of scientist from University of Limburg, now Maastricht University. In 90’s they published some interesting works about the role of adrenergic receptors. Surprisingly this study is still on going and new approaches are used. In 1993, Blaak was studying the role … Baca lebih lanjut

What do we know about our own fat?

Adipose tissue has gained popularity and better understanding these days. The increasing prevalence of obesity and its related disease is forcing science to provide a better understand on what is adipocyte. This tissue is not just a pocket of energy where mamalians put their extra energy. Adipocyte is an endocrine cell, which literally has ability … Baca lebih lanjut