Exercise and beyond: improvement of SOD and the role of oxidative stress

Exercise is good for your health that, my grandmother knows that. A routine exercise is able to help you reduce weight and prevent weight gain, public secret. But how can exercise help against obesity, the answer is not as simple as just doing the math.

Farias et al from the laboratory of biochemistry and physiology, Universidade do Extremo Sul Catarunense Brazil showed an interesting study. On the paper that is just published recently, they shown that physical exercise could be able to help prevent weight gain by modulating the oxidative stress in adipose tissue. In order to conduct this study, they used 4 groups of treatment in mice model: 1) group receive standard diet; 2) group receive standard diet with exercise; 3) group receive high fat diet; 4) high fat diet with exercise. From these treatments they found that group with high fat diet had the hisghest weight while group with standard diet plus exercise has the lowest weight after treatment. As expected, additional exercise could significantly prevent weight gain.

What make this study interesting is that they do analyzed factors that related to oxidative stress and tested whether exercise can changed the condition. ROS or reactive oxygen species is already studied related to obesity before. In the study, they shown that exercise could be able to reduce oxidative stress by improving superoxide dysmutase or SOD activity in epididymal fat.

Additionally, they wanted to see wheter exercise also be able to improve lipolysis process by analyzing adypocye triglyceride lipase (ATGL). This enzyme is downstream signal from beta adrenergic receptor and important in lipolysis process. In previous findings, studies shown that ATGL level is reduce in adipose tissue of obese individuals. This lead to a general assumption that level of ATGL is representative for lipolysis process in adipose tissue. In this study, Farias et al shown that exercise in high fat diet could increased significantly ATGL level in mice adipocyte compared to the other treatment. However this finding leads to some big question mark, why ATGL level was not increased in standard diet with exercise?

Indeed, this study clearly proven new theory how exercise could help reduce weight by improving our resistance against oxidative stress. If the oxiative stress is the black sheep that makes an obese person has a hard time to lose weight, treatment using antioxidant could be recommened during weight loss program in the future. And yes, lets not forget the 20 minutes at the treadmill.

Source:
http://www.ncbi.nlm.nih.gov/pubmed/22972182

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