TCF7L2 and weight loss

There are some genes that widely known to be related to weight regulation. Some of them play important role in adipogenesis, while the others regulate glucose metabolism. TCF7L2 or transcription factor 7 like 2 is a gene that encode protein involved in blood glucose homeostasis. Interestingly, this gene is reported not only regulates glucose metabolism but also a wider systemic processes. Studies shown that TCF7L2 be regulates adipogenesis indirectly via Wnt signalling. Some evidences also shown that this gene is associated with appetite and food intake.

Recent study done by Mattei et al. shown that invidual with rs12255372 risk genotype of TCF7L2 be able to reduce total body fat by low fat diet after 2 years. This study was done in Boston, Massachusetts, and Baton Rouge, Lousiana, USA. In the study, about 811 overweight and obese adults were divided into 4 diet groups with different composition of fat, carbohydrate and protein. Those combination could be low fat, low protein or low carbohydrate.

After 2 years monitored and guided by dietitian, subjects were sucessfully lost their weight. And when individuals with risk allele for rs12255372 receive low fat (20% of total energy) diet, they lose more BMI compared to individuals carrying C allele. Thus, the authors suggested that overweight and obese with TCF7L2 variants might obtain greater benefit of reducing body fat using low fat diet.

Mattei J, et al. TCF7L2 genetic variants modulate the effect of dietary fat intake on body composition during weight loss intervention. American Journal of Clinical Nutrition, 2012, 96; 1129-36.

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